BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-076268 (Published 17 April 2024)Cite this as: BMJ 2024;385:e076268
Conclusions
Antipsychotic use compared with non-use in adults with dementia was associated with increased risks of stroke, venous thromboembolism, myocardial infarction, heart failure, fracture, pneumonia, and acute kidney injury, but not ventricular arrhythmia. The range of adverse outcomes was wider than previously highlighted in regulatory alerts, with the highest risks soon after initiation of treatment.